Also called: Penile disorders
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Penis Disorders
Problems with the penis can cause pain and affect a man's sexual function and fertility. Penis disorders include:
- Erectile dysfunction - inability to get or keep an erection
- Priapism - a painful erection that does not go away
- Peyronie's disease - bending of the penis during an erection due to a hard lump called a plaque
- Balanitis - inflammation of the skin covering the head of the penis, most often in men and boys who have not been circumcised
- Penile cancer - a rare form of cancer, highly curable when caught early
It sits within Men, Sexual Health Issues and Male Reproductive System.
The lead U.S. institute for this subject is the National Institute of Diabetes and Digestive and Kidney Diseases.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Penis Disorders
401 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary TumorsNational Cancer Institute (NCI)
- EGFR-ADC (Becotatug Vedotin) Combined With PD-1 Inhibitor (Pucotenlimab) in Neoadjuvant Treatment of Advanced Penile CancerJiyan Liu
- Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias SurgeryMedipol University
- Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis PlacementRush University Medical Center
- Nivolumab Combined With Ipilimumab for Patients With Advanced Rare Genitourinary TumorsDana-Farber Cancer Institute
- Genetics of Differences of Sex Development and HypospadiasBoston Children's Hospital
Research already completed
- Validation of ICG-99mTc-nanoscan as Hybrid Tracer for Sentinel Node BiopsyThe Netherlands Cancer Institute
- the Efficacy and Safety of LDP in Patients With Urinary and Male Genital TumorsDragonboat Biopharmaceutical Company Limited
- Combination Immunotherapy in Subjects With Advanced HPV Associated MalignanciesNational Cancer Institute (NCI)
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- Penis Health: Identify and Prevent ProblemsMayo Foundation for Medical Education and Research
Diagnosis and Tests
- Early Detection, Diagnosis, and Staging for Penile CancerAmerican Cancer Society
- Genital Problems in MenAmerican Academy of Family Physicians
- Penile Cancer StagesNational Cancer Institute
Treatments and Therapies
- Drugs Approved for Penile CancerNational Cancer Institute
- Penile Cancer TreatmentNational Cancer Institute
Prevention and Risk Factors
- Causes, Risk Factors, and Prevention of Penile CancerAmerican Cancer Society
Living With
- After Treatment for Penile CancerAmerican Cancer Society
Related Issues
- Penis-Enlargement Products: Do They Work?Mayo Foundation for Medical Education and Research
Statistics and Research
- Key Statistics for Penile CancerAmerican Cancer Society
Clinical Trials
- ClinicalTrials.gov: Genital Diseases, MaleNational Institutes of Health
- ClinicalTrials.gov: Penile DiseasesNational Institutes of Health
- ClinicalTrials.gov: Penile IndurationNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Penile Diseases. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Penis Disorders, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.