Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Male Infertility
Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. Causes of male infertility include:
- Physical problems with the testicles
- Blockages in the ducts that carry sperm
- Hormone problems
- A history of high fevers or mumps
- Genetic disorders
- Lifestyle or environmental factors
About a third of the time, infertility is because of a problem with the man. One third of the time, it is a problem with the woman. Sometimes no cause can be found.
If you suspect you are infertile, see your doctor. There are tests that may tell if you have fertility problems. When it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technology. Happily, many couples treated for infertility are able to have babies.
It sits within Men and Male Reproductive System.
The lead U.S. institute for this subject is the Eunice Kennedy Shriver National Institute of Child Health and Human Development.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Male Infertility
466 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- Inherited Reproductive DisordersNational Institute of Environmental Health Sciences (NIEHS)
- Experimental Round Spermatid Injection (ROSI) to Treat Infertile CouplesWake Forest University Health Sciences
- Sperm, Exposure and Endocrine DisruptorsMillion Marker Wellness, Inc.
- Maternal Inheritance of a Pathogenic MT-ND1 Mutation Causes Mitochondrial Dysfunction and Spermatogenic Failure in MenThe Third Affiliated Hospital of Guangzhou Medical University
- A Randomized Clinical Trial Comparing Embryo Euploidy Rates Following Ultrashort Versus Standard AbstinenceUConn Health
- Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen ParametersFakih IVF Fertility Center
Research already completed
- Hormonal Regulation of Puberty and FertilityNational Institute of Environmental Health Sciences (NIEHS)
- Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.Tehran University of Medical Sciences
- The Clinical Study of Sex Chromosome VariantsNational Human Genome Research Institute (NHGRI)
- Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile MenUniversity Hospital, Rouen
- Evaluation of FPT-20 for the Treatment of Spermatogenesis and Semen DisordersTrieu, Nguyen Thi, M.D.
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- How Common is Male Infertility, and What Are Its Causes?Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Male InfertilityMayo Foundation for Medical Education and Research
Diagnosis and Tests
- Semen AnalysisNational Library of Medicine
- Testosterone Levels TestNational Library of Medicine
Treatments and Therapies
- Assisted Reproductive Technology: MedlinePlus Health TopicNational Library of Medicine
- Healthy Sperm: Improving Your FertilityMayo Foundation for Medical Education and Research
- Intrauterine Insemination (IUI)Mayo Foundation for Medical Education and Research
- What Is Intracytoplasmic Sperm Injection (ICSI)?American Society for Reproductive Medicine
- What Treatment Options Are Available for Male Infertility?Eunice Kennedy Shriver National Institute of Child Health and Human Development
Living With
- Foods That Can Affect FertilityAcademy of Nutrition and Dietetics
Related Issues
- Fertility Issues in Boys and Men with CancerNational Cancer Institute
- Finasteride and PregnancyOrganization of Teratology Information Specialists
- Hypogonadism in MenEndocrine Society
Genetics
- 48,XXYY syndrome: MedlinePlus GeneticsNational Library of Medicine
- About Klinefelter SyndromeNational Human Genome Research Institute
- Congenital bilateral absence of the vas deferens: MedlinePlus GeneticsNational Library of Medicine
- Globozoospermia: MedlinePlus GeneticsNational Library of Medicine
- Macrozoospermia: MedlinePlus GeneticsNational Library of Medicine
- Sensorineural deafness and male infertility: MedlinePlus GeneticsNational Library of Medicine
- X-linked adrenal hypoplasia congenita: MedlinePlus GeneticsNational Library of Medicine
Clinical Trials
- ClinicalTrials.gov: Infertility, MaleNational Institutes of Health
- ClinicalTrials.gov: OligospermiaNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Infertility, Male. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Male Infertility, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.