Also called: Nephroblastoma
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Wilms Tumor
Wilms tumor is a rare type of kidney cancer. It causes a tumor on one or both kidneys. It usually affects children, but can happen in adults. Having certain genetic conditions or birth defects can increase the risk of getting it. Children that are at risk should be screened for Wilms tumor every three months until they turn eight.
Symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. Tests that examine the kidney and blood are used to find the tumor.
Doctors usually diagnose and remove the tumor in surgery. Other treatments include chemotherapy and radiation and biologic therapies. Biologic therapy boosts your body's own ability to fight cancer.
It sits within Cancers and Kidneys and Urinary System.
The lead U.S. institute for this subject is the National Cancer Institute.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Wilms Tumor
265 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell TumorNational Cancer Institute (NCI)
- Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)National Cancer Institute (NCI)
- Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare TumorsNational Cancer Institute (NCI)
- FH-WT1-E50 TCR T Cells With Azacitidine for the Treatment of Minimal Residual Disease Positive Acute Myeloid LeukemiaFred Hutchinson Cancer Center
- Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment TrialNational Cancer Institute (NCI)
- Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)National Cancer Institute (NCI)
Research already completed
- Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' TumorChildren's Oncology Group
- Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALLUniversity Hospital, Angers
- First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer PatientsUniversity Hospital, Antwerp
- Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine GliomaUniversity Hospital, Antwerp
- Combination Chemotherapy and Surgery in Treating Young Patients With Wilms TumorChildren's Oncology Group
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- General Information about Wilms Tumor and Other Childhood Kidney TumorsNational Cancer Institute
- What Are Wilms Tumors?American Cancer Society
- Wilms TumorNemours Foundation
Symptoms
- Signs and Symptoms of Wilms TumorsAmerican Cancer Society
Diagnosis and Tests
- Stages of Wilms TumorNational Cancer Institute
- Tests for Wilms TumorsAmerican Cancer Society
Treatments and Therapies
- Drugs Approved for Wilms Tumor and Other Childhood Kidney CancersNational Cancer Institute
- Nephrectomy (Kidney Removal)Mayo Foundation for Medical Education and Research
- Treatment Option Overview (Wilms Tumor and Other Childhood Kidney Tumors)National Cancer Institute
Prevention and Risk Factors
- Can Wilms Tumors Be Found Early?American Cancer Society
Related Issues
- Solitary or Single-Functioning KidneyNational Institute of Diabetes and Digestive and Kidney Diseases
Genetics
- WAGR syndrome: MedlinePlus GeneticsNational Library of Medicine
- Wilms tumor: MedlinePlus GeneticsNational Library of Medicine
Clinical Trials
- ClinicalTrials.gov: Wilms TumorNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Wilms Tumor. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Wilms Tumor, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.