Health Topic

Steatotic Liver Disease

Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. Learn about the causes and treatments.

Reviewed Reviewed by a registered pharmacistGeneral information

Also called: ALD · Alcohol-associated liver disease · Alcoholic fatty liver disease · Fatty Liver Disease · MASLD · Metabolic dysfunction-associated steatotic liver disease · NAFLD · Nonalcoholic fatty liver disease · SLD

Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.

About Steatotic Liver Disease

Your liver is the largest organ inside your body. It helps you digest food, store energy, and remove harmful substances (toxins). Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. It's typical to have some fat in your liver cells, but too much can be a problem.

There are two main types of steatotic liver disease:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD)
  • Alcohol-associated liver disease (ALD)

MASLD is a type of steatotic liver disease that is not caused by heavy alcohol use. It used to be called nonalcoholic fatty liver disease. There are two main forms:

  • Simple fatty liver, in which you have fat in your liver but little or no inflammation or liver damage. This form usually does not get bad enough to cause liver damage or complications.
  • Metabolic dysfunction-associated steatohepatitis, or MASH (previously called nonalcoholic steatohepatitis or NASH), is when MASLD gets worse. In addition to fat in your liver, MASH may cause inflammation and liver damage. This can lead to fibrosis, or scarring, of the liver. This scarring sometimes leads to cirrhosis or liver cancer.

ALD is caused by heavy alcohol use. It used to be called alcoholic fatty liver disease, or alcoholic steatohepatitis.

Your liver breaks down most of the alcohol you drink, so it can be removed from your body. But the process of breaking it down can create harmful substances. These substances can damage liver cells, cause inflammation, and weaken your body's natural defenses. The more alcohol that you drink, the more you damage your liver. ALD is the earliest stage of alcohol-related liver disease. The next stages are alcoholic hepatitis and cirrhosis.

The cause of MASLD is unknown, but it is more common in people who:

  • Have type 2 diabetes and prediabetes
  • Have obesity
  • Are middle aged or older (although children can also get it)
  • Have high cholesterol or triglycerides
  • Have high blood pressure
  • Take certain medicines, such as corticosteroids and some cancer medicines
  • Have certain metabolic disorders, including metabolic syndrome
  • Have rapid weight loss
  • Have certain infections, such as hepatitis C
  • Have been exposed to certain harmful substances

MASLD is the most common chronic (long-term) liver disease due to increasing rates of obesity, type 2 diabetes, and high cholesterol.

ALD only happens in people who are heavy drinkers, especially those who have been drinking for a long period of time. The risk is higher for people who drink heavily and are women, have obesity, or have certain gene changes (known as variants or mutations).

Both MASLD and ALD usually have few or no symptoms. If you do have symptoms, you may feel tired or have discomfort in the upper right side of your abdomen (belly).

Because there are often no symptoms, it's not easy to find steatotic liver disease. Your health care provider may suspect you have it if you have abnormal results on liver tests. To make a diagnosis, your provider may use:

  • Your medical history. This may include asking about your alcohol use and any medicines you take.
  • A physical exam. This may include checking your height and weight. Your provider may also check your body for signs of liver disease such as an enlarged liver or jaundice, a condition that causes your skin and whites of your eyes to turn yellow.
  • Blood tests. These may include liver function tests and blood count tests.
  • Imaging tests. These tests may be used to check for fat in the liver and for fibrosis.
  • A biopsy. In some cases, a biopsy may be done to confirm the diagnosis and check for liver damage.

The first step in treating MASLD is usually weight loss. Losing weight can reduce fat in the liver, inflammation, and fibrosis. If your provider thinks that a certain medicine is the cause of your MASLD, they may tell you to stop or switch medicines. But don't stop taking any medicines unless your provider tells you to.

More studies are needed to see whether certain medicines are safe and effective to treat MASLD. Currently, no medicines are approved for treatment.

The most important part of treating ALD is to stop drinking alcohol. If you need help, you may benefit from counseling, a recovery program, or medicines that reduce cravings or make you feel sick if you drink alcohol.

Both ALD and one type of MASLD can lead to cirrhosis. Health problems caused by cirrhosis may be treated with medicines, surgery, and other medical procedures. If cirrhosis leads to liver failure, you may need a liver transplant.

If you have any type of steatotic liver disease, there are some lifestyle changes that can help:

  • Eat a healthy diet, limiting salt and sugar, plus eating lots of fruits, vegetables, and whole grains.
  • Talk with your provider about vaccinations. If you have chronic liver disease you are more likely to get infections. Your provider may recommend vaccinations for hepatitis A and B, the flu and pneumococcal disease.
  • Get regular exercise, which can help you lose weight and reduce fat in the liver.

Check with your provider before using dietary supplements, such as vitamins, or any complementary or alternative medicines or medical practices. Some supplements or herbal remedies can damage the liver.

It sits within Digestive System.

The lead U.S. institute for this subject is the National Institute of Diabetes and Digestive and Kidney Diseases.

When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.

Research on Steatotic Liver Disease

224 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.

What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.

Research currently under way

Research already completed

Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.

Where to read more

Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.

Learn More

Genetics

Clinical Trials

Medical subject headings

Clinicians and researchers index this subject under Fatty Liver, Non-alcoholic Fatty Liver Disease, Fatty Liver, Alcoholic. These are the terms to use when searching medical literature.

This page is built from the MedlinePlus health topic record for Steatotic Liver Disease, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.