Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Pemphigus
Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus.
Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients.
Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include:
- Steroids, which reduce inflammation
- Drugs that suppress the immune system response
- Antibiotics to treat associated infections
It sits within Skin, Hair and Nails and Immune System.
The lead U.S. institute for this subject is the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Pemphigus
87 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- A Study to Investigate Safety and Efficacy of KB111 for the Treatment of Hailey-Hailey DiseaseKrystal Biotech, Inc.
- ONO-4059 Study in Patients With Steroid-resistant PemphigusOno Pharmaceutical Co., Ltd.
- CD19 CAR-T Therapy for Refractory Pemphigus VulgarisJinbo Chen
- Efficacy of Guselkumab in Treating Hailey Hailey DiseaseYale University
- Comparison of the Efficacy of Clobetasol Propionate 0.05% Mouthwash, Photobiomodulation, and Their Combination in Managing of Oral Lesions in Patient With Pemphigus Vulgaris.Damascus University
- A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)Cabaletta Bio
Research already completed
- Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the "RITUXIMAB 3" TrialUniversity Hospital, Rouen
- Effect of Topical Insulin on Healing Rate of Pemphigus LesionsAlexandria University
- Efficacy and Safety of Different Doses of Rituximab Therapy in Pemphigus PatientsRuijin Hospital
- Evaluating Legit.Health Plus Support for Improving Diagnosis of Generalized Pustular Psoriasis and Other Skin Conditions Among Primary Care Physicians and DermatologistsAI Labs Group S.L
- Identification of Vulnerability Factors in the Course of Pemphigus PatientsUniversity Hospital, Rouen
- Wildfire Related Air Pollution Exposure and Cognitive Function Pilot StudyRutgers, The State University of New Jersey
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- PemphigusNational Institute of Arthritis and Musculoskeletal and Skin Diseases
Clinical Trials
- ClinicalTrials.gov: Pemphigoid, Benign Mucous MembraneNational Institutes of Health
- ClinicalTrials.gov: Pemphigoid, BullousNational Institutes of Health
- ClinicalTrials.gov: PemphigusNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Pemphigoid Gestationis, Pemphigoid, Benign Mucous Membrane, Pemphigus, Pemphigoid, Bullous, Pemphigus, Benign Familial. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Pemphigus, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.