Also called: Malignant mesothelioma
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Mesothelioma
The tissue that lines your lungs, stomach, heart, and other organs is called mesothelium. Mesothelioma, also known as malignant mesothelioma, is cancer of that tissue. It usually starts in the lungs, but can also start in the abdomen or other organs.
Malignant mesothelioma is rare but serious. Most people who get it have worked or lived in places where they inhaled or swallowed asbestos particles. After being exposed to asbestos, it usually takes a long time for the disease to form.
Symptoms include:
- Trouble breathing
- Cough
- Pain under the rib cage
- Pain, swelling, or lumps in the abdomen
- Weight loss for no known reason
- Blood clots
- Constipation
- Fatigue
Sometimes it is hard to tell the difference between malignant mesothelioma and lung cancer. To find out if you have mesothelioma, your health care provider will likely use a physical exam, imaging tests, and a biopsy.
Malignant mesothelioma is often found when it is advanced. This makes it harder to treat. Treatment options may include:
- Surgery
- Radiation therapy
- Chemotherapy
- Immunotherapy
- Targeted therapy, which uses drugs or other substances that attack specific cancer cells with less harm to normal cells
It sits within Cancers and Lungs and Breathing.
The lead U.S. institute for this subject is the National Cancer Institute.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Mesothelioma
604 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid TumorsTreeline Biosciences, Inc.
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal HistologiesNational Cancer Institute (NCI)
- MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural MesotheliomaAstraZeneca
- Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Subjects With Unresectable Malignant MesotheliomaMedImmune LLC
- Chemotherapy With or Without Immunotherapy for Peritoneal MesotheliomaNational Cancer Institute (NCI)
- Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1National Cancer Institute (NCI)
Research already completed
- Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including MesotheliomaRS Oncology LLC
- BEAT-meso: Bevacizumab and Atezolizumab in Malignant Pleural MesotheliomaETOP IBCSG Partners Foundation
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- MesotheliomaAmerican Cancer Society
- MesotheliomaMayo Foundation for Medical Education and Research
- What Is Mesothelioma?National Cancer Institute
Diagnosis and Tests
- Early Detection, Diagnosis, and Staging of MesotheliomaAmerican Cancer Society
- Mesothelioma StagesNational Cancer Institute
Treatments and Therapies
- Drugs Approved for Malignant MesotheliomaNational Cancer Institute
- Mesothelioma TreatmentNational Cancer Institute
Prevention and Risk Factors
- Causes, Risk Factors, and Prevention of MesotheliomaAmerican Cancer Society
- Learn about MesotheliomaAmerican Lung Association
Related Issues
- Asbestos Exposure and Cancer RiskNational Cancer Institute
Statistics and Research
- Key Statistics about Malignant MesotheliomaAmerican Cancer Society
Clinical Trials
- ClinicalTrials.gov: MesotheliomaNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Mesothelioma. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Mesothelioma, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.