Also called: Non-Hodgkin lymphoma
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Lymphoma
Lymphoma is a cancer of a part of the immune system called the lymph system. There are many types of lymphoma. One type is Hodgkin disease. The rest are called non-Hodgkin lymphomas.
Non-Hodgkin lymphomas begin when a type of white blood cell, called a T cell or B cell, becomes abnormal. The cell divides again and again, making more and more abnormal cells. These abnormal cells can spread to almost any other part of the body. Most of the time, doctors don't know why a person gets non-Hodgkin lymphoma. You are at increased risk if you have a weakened immune system or have certain types of infections.
Non-Hodgkin lymphoma can cause many symptoms, such as :
- Swollen, painless lymph nodes in the neck, armpits or groin
- Unexplained weight loss
- Fever
- Soaking night sweats
- Coughing, trouble breathing or chest pain
- Weakness and tiredness that don't go away
- Pain, swelling or a feeling of fullness in the abdomen
Your doctor will diagnose lymphoma with a physical exam, blood tests, a chest x-ray, and a biopsy. Treatments include chemotherapy, radiation therapy, targeted therapy, biological therapy, or therapy to remove proteins from the blood. Targeted therapy uses drugs or other substances that attack specific cancer cells with less harm to normal cells. Biologic therapy boosts your body's own ability to fight cancer. If you don't have symptoms, you may not need treatment right away. This is called watchful waiting.
It sits within Cancers and Immune System.
The lead U.S. institute for this subject is the National Cancer Institute.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Lymphoma
11,208 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)National Cancer Institute (NCI)
- Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic LeukemiaChildren's Oncology Group
- Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or VenetoclaxNational Heart, Lung, and Blood Institute (NHLBI)
- Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic SyndromeChildren's Oncology Group
- Anti-CRLF2-R/TSLPR Chimeric Antigen Receptor T Cells (TSLPR-CART) in Participants With Recurrent or Refractory CRLF2-R/TSLPR-Overexpressing B-Cell Acute Lymphoblastic Leukemia (B-ALL)National Cancer Institute (NCI)
- Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCLAllogene Therapeutics
Research already completed
- Venetoclax in Combination With BEAM Conditioning Regimen for ASCT in Non-Hodgkin LymphomaCase Comprehensive Cancer Center
- Olaparib and High-Dose Chemotherapy in Treating Patients With Relapsed or Refractory Lymphomas Undergoing Stem Cell TransplantM.D. Anderson Cancer Center
- CMC-544 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL)M.D. Anderson Cancer Center
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- General Information about Adult Non-Hodgkin LymphomaNational Cancer Institute
- General Information about Childhood Non-Hodgkin LymphomaNational Cancer Institute
Diagnosis and Tests
- Beta 2 Microglobulin (B2M) Tumor Marker TestNational Library of Medicine
- Blood Count Tests: MedlinePlus Health TopicNational Library of Medicine
- Bone Marrow TestsNational Library of Medicine
- Lab and Imaging TestsBlood Cancer United
Treatments and Therapies
- Bone Marrow Transplantation: MedlinePlus Health TopicNational Library of Medicine
- Drugs Approved for Non-Hodgkin LymphomaNational Cancer Institute
- ImmunotherapyBlood Cancer United
- Integrative Medicine and Complementary TherapiesBlood Cancer United
Prevention and Risk Factors
- Can Non-Hodgkin Lymphoma Be Prevented?American Cancer Society
- Causes, Risk Factors, and Prevention of Waldenstrom MacroglobulinemiaAmerican Cancer Society
Living With
- After Treatment for Waldenstrom MacroglobulinemiaAmerican Cancer Society
- Living as a Non-Hodgkin Lymphoma SurvivorAmerican Cancer Society
Related Issues
- Hodgkin's vs. Non-Hodgkin's Lymphoma: What's the Difference?Mayo Foundation for Medical Education and Research
Genetics
- 8p11 myeloproliferative syndrome: MedlinePlus GeneticsNational Library of Medicine
- Mycosis fungoides: MedlinePlus GeneticsNational Library of Medicine
Statistics and Research
- Advances in Lymphoma ResearchNational Cancer Institute
- Cancer Stat Facts: Non-Hodgkin LymphomaNational Cancer Institute
- Key Statistics for Non-Hodgkin LymphomaAmerican Cancer Society
Clinical Trials
- Blood Cancer UnitedBlood Cancer United
- ClinicalTrials.gov: LymphomaNational Institutes of Health
- ClinicalTrials.gov: Lymphoma, Non-HodgkinNational Institutes of Health
- ClinicalTrials.gov: Waldenstrom MacroglobulinemiaNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Lymphoma. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Lymphoma, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.