Also called: Nephrolithiasis
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About Kidney Stones
A kidney stone is a solid piece of material that forms in the kidney from substances in the urine. It may be as small as a grain of sand or as large as a pearl. Most kidney stones pass out of the body without help from a doctor. But sometimes a stone will not go away. It may get stuck in the urinary tract, block the flow of urine and cause great pain.
The following may be signs of kidney stones that need a doctor's help:
- Extreme pain in your back or side that will not go away
- Blood in your urine
- Fever and chills
- Vomiting
- Urine that smells bad or looks cloudy
- A burning feeling when you urinate
Your doctor will diagnose a kidney stone with urine, blood, and imaging tests.
If you have a stone that won't pass on its own, you may need treatment. It can be done with shock waves; with a scope inserted through the tube that carries urine out of the body, called the urethra; or with surgery.
It sits within Kidneys and Urinary System.
The lead U.S. institute for this subject is the National Institute of Diabetes and Digestive and Kidney Diseases.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on Kidney Stones
784 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- 2D:4D Digit Ratio and Urinary Stone DiseaseEmrah Kızılay
- Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1Calcilytix Therapeutics, Inc., a BridgeBio company
- PCNL Versus RIRS for Management of Stones in Solitary KidneyMansoura University
- Trial of Ureteroscopy vs Steerable Continuous Flow Aspiration TechnologyCalyxo, Inc.
- Nephrostomy Tract Infiltration for Pain Control After PCNLHitit University
- Observational Approach Versus Surgical Intervention for StonesChildren's Hospital of Philadelphia
Research already completed
- Safety and Efficacy of Fluoroscopy-free Technique During Retrograde Intrarenal Surgery for Renal StonesAl-Azhar University
- Mini-PNL, RIRS, and ESWL for Treatment of Medium-Sized, High-Density, Non-Lower Pole, Renal StonesAl-Azhar University
- Erector Spinae Plane Block for Analgesia During ESWLSohag University
- Erector Spinae Plane Block for Percutaneous NephrolithotomyFadime Tosun
- Vitamin E Supplementation Effect in Management of Calcium Oxalate CrystalsUniversity of Lahore
- Ultrasound Imaging of Kidney Stones and LithotripsyUniversity of Washington
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- Definition and Facts for Kidney StonesNational Institute of Diabetes and Digestive and Kidney Diseases
- Kidney StonesNational Kidney Foundation
- Kidney StonesNational Institute of Diabetes and Digestive and Kidney Diseases
- Pebbles in Your Plumbing: Flushing Kidney StonesNational Institutes of Health
Diagnosis and Tests
- Abdominal Pain (Stomach Pain), Short-TermAmerican Academy of Family Physicians
- Crystals in UrineNational Library of Medicine
- Kidney Stone AnalysisNational Library of Medicine
- Kidney Tests: MedlinePlus Health TopicNational Library of Medicine
- Phosphate in UrineNational Library of Medicine
- Uric Acid TestNational Library of Medicine
- UrographyRadiological Society of North America
Treatments and Therapies
- Kidney Stone TreatmentNational Kidney Foundation
Prevention and Risk Factors
- Preventing Kidney StonesDepartment of Veterans Affairs
Living With
- Eating, Diet, and Nutrition for Kidney StonesNational Institute of Diabetes and Digestive and Kidney Diseases
- Kidney Stone Diet Plan and PreventionNational Kidney Foundation
Genetics
- Cystinuria: MedlinePlus GeneticsNational Library of Medicine
- Hereditary xanthinuria: MedlinePlus GeneticsNational Library of Medicine
- Kidney stones: MedlinePlus GeneticsNational Library of Medicine
- Primary hyperoxaluria: MedlinePlus GeneticsNational Library of Medicine
Statistics and Research
- Kidney Stones: Learn More -- Preventing Kidney StonesNational Center for Biotechnology Information
Clinical Trials
- ClinicalTrials.gov: NephrolithiasisNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Nephrolithiasis. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for Kidney Stones, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.