Also called: Gastroesophageal reflux disease
Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.
About GERD
Sometimes, after eating a large meal or lying down too soon after eating, you might feel acid coming up into your throat. This is called gastroesophageal reflux (GER). It happens when the muscle at the end of your esophagus (the tube that carries food from your mouth to your stomach) doesn't close properly. Stomach contents can then move back up and irritate the esophagus.
Having reflux occasionally is common. But if you have symptoms two or more times a week or if they cause damage to the lining of your esophagus, you may have gastroesophageal reflux disease (GERD). GERD is a chronic (long-lasting) condition that can cause discomfort and, over time, lead to other health problems.
Anyone can have GERD, including infants and children.
GERD can happen when the muscle at the bottom of your esophagus becomes weak or relaxes at the wrong time. You are more likely to have GERD if you:
- Are overweight or have obesity
- Are pregnant
- Smoke or are around secondhand smoke
- Have a hiatal hernia (when part of the stomach pushes up into the chest)
Certain foods, drinks, or medicines can also make GERD worse.
The most common symptom of GERD is heartburn. This is a burning feeling in your chest or throat. You can also have GERD without having heartburn. Other symptoms may include:
- Tasting acid or food in the back of your mouth
- A dry cough or hoarse voice
- Asthma-like symptoms
- Trouble swallowing
Get medical help right away if you have chest pain with shortness of breath, or pain in your jaw or arm. These can be signs of a heart problem.
Your health care provider will ask about your symptoms and medical history. They may recommend tests such as:
- Upper GI endoscopy to look at the esophagus and stomach lining with a tiny camera.
- Biopsy to check a small tissue sample.
- X-Ray to take pictures of the upper digestive system.
- Esophageal pH test to measure how often acid backs up the esophagus and how long the acid stays there.
- Esophageal manometry to check how well your esophagus moves food when you swallow.
- Transnasal esophagoscopy to look for damage to the esophagus by using a small tube with a camera.
Most people can manage GERD with lifestyle changes and medicine. In rare cases, surgery is needed.
Lifestyle changes can include:
- Eating smaller meals and avoiding lying down for at least 2-3 hours after eating
- Avoiding foods that trigger symptoms, such as spicy foods, chocolate, caffeine, or fatty foods
- Losing weight if needed
- Raising the head of your bed
- Quitting smoking
Medicines can include:
- Over-the-counter medicines, such as antacids
- Prescription medicines
If not treated, GERD can cause problems like inflammation of the esophagus, scarring, or changes in the tissue lining (Barrett's esophagus). It can also worsen asthma or cause chronic (long-term) cough or hoarseness.
You may be able to improve symptoms of GERD by:
- Avoiding alcohol and trigger foods
- Eating smaller meals
- Not eating close to bedtime
- Wearing loose-fitting clothes
- Sleeping on your left side or raising the head of your bed
- Maintaining a healthy weight
It sits within Digestive System.
The lead U.S. institute for this subject is the National Institute of Diabetes and Digestive and Kidney Diseases.
When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.
Research on GERD
1,354 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.
What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.
Research currently under way
- Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 as Maintenance Therapy in Subjects With Healed Erosive EsophagitisOnconic Therapeutics Inc.
- Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy VolunteersKorea United Pharm. Inc.
- Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.AstraZeneca
- Transit Bipartition After Sleeve GastrectomyHospital das Clínicas de Ribeirão Preto
- Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:Medical College of Wisconsin
- Transventricular Off-pump Mitral Valve RepairJohns Hopkins University
Research already completed
- A Study to Check the Safety of Dexlansoprazole and Learn if it Can Treat Symptomatic Nonerosive Gastroesophageal Reflux Disease in Children 2 to 11 Years OldTakeda
- Endoscopic Classification of Fundoplication Integrity Predicts Pathologic RefluxIRCCS Policlinico S. Donato
- Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERDMicrobiome Health Sciences
- Early Feasibility Study of the Neovasc Tiara™ Mitral Valve SystemShockwave Medical, Inc.
- Thresholds of SLR Maneuver in Obese PatientsIRCCS Policlinico S. Donato
Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.
Where to read more
Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.
Start Here
- Acid Reflux (GER and GERD) in AdultsNational Institute of Diabetes and Digestive and Kidney Diseases
- Gastroesophageal Reflux Disease (GERD)Mayo Foundation for Medical Education and Research
Symptoms
- Is It Really GERD?Harvard Medical School
Diagnosis and Tests
- Barium SwallowNational Library of Medicine
- Esophageal pH TestNational Library of Medicine
- pH Impedance StudyNorth American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- Upper GI -- Esophagram -- Barium SwallowRadiological Society of North America
- Upper GI EndoscopyNational Institute of Diabetes and Digestive and Kidney Diseases
Treatments and Therapies
- Antacids and Acid Reducers: OTC Relief for Heartburn and Acid RefluxAmerican Academy of Family Physicians
- Feeling the Burn? Options for Acid RefluxNational Institutes of Health
- Fundoplication (For Children)North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- Gastroesophageal reflux - seriesMedical Encyclopedia
Related Issues
- Esophageal SpasmsMayo Foundation for Medical Education and Research
- Gastroesophageal Reflux DiseaseAmerican Academy of Allergy, Asthma, and Immunology
- GERD: Can Certain Medications Make It Worse?Mayo Foundation for Medical Education and Research
- IndigestionAmerican Academy of Family Physicians
- Non-Cardiac Chest PainAmerican College of Gastroenterology
- Warning: Aspirin-Containing Antacid Medicines Can Cause BleedingFood and Drug Administration
Clinical Trials
- ClinicalTrials.gov: Gastroesophageal RefluxNational Institutes of Health
Medical subject headings
Clinicians and researchers index this subject under Gastroesophageal Reflux. These are the terms to use when searching medical literature.
This page is built from the MedlinePlus health topic record for GERD, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.