Health Topic

C. diff Infections

C. diff or C. difficile is a bacterium that causes diarrhea. You are more likely to get C. diff if you take antibiotics or are an older adult.

Reviewed Reviewed by a registered pharmacistGeneral information

Also called: Clostridioides difficile infections · Clostridium difficile Infections · Clostridium enterocolitis · Pseudomembranous colitis

Important: This page is general information, not medical advice. It does not recommend or prescribe any treatment. Always consult your doctor or pharmacist before starting, stopping or changing any medicine.

About C. diff Infections

C. diff is a bacterium that can cause diarrhea and more serious intestinal conditions such as colitis. You may see it called other names, such as Clostridioides difficile (the new name), Clostridium difficile (an older name), and C. difficile. It causes close to half a million illnesses each year.

C. diff bacteria are commonly found in the environment, but people usually only get C. diff infections when they are taking antibiotics. That's because antibiotics not only wipe out bad germs, but they also kill the good germs that protect your body against infections. The effect of antibiotics can last as long as several months. If you come in contact with C. diff germs during this time, you can get sick. You are more likely to get a C. diff infection if you take antibiotics for more than a week.

C. diff spreads when people touch food, surfaces, or objects that are contaminated with feces (poop) from a person who has C. diff.

You are at more likely to get a C. diff infection if you:

  • Are taking antibiotics
  • Are 65 or older
  • Recently stayed in a hospital or nursing home
  • Have a weakened immune system
  • Have had a previous infection with C. diff or were exposed to it

The symptoms of C. diff infections include:

  • Diarrhea (loose, watery stools) or frequent bowel movements for several days
  • Fever
  • Stomach tenderness or pain
  • Loss of appetite
  • Nausea

Severe diarrhea causes you to lose a lot of fluids. This can put you at risk for dehydration.

If you have been taking antibiotics recently and have symptoms of a C. diff infection, you should see your health care provider. Your provider will ask about your symptoms and do a lab test of your stool. In some cases, you might also need an imaging test such as an x-ray or CT scan to check for complications.

Certain antibiotics can treat C. diff infections. If you were already taking a different antibiotic when you got C. diff, your provider may ask you to stop taking that one.

If you have a severe case, you may need to stay in the hospital. If you have very severe pain or serious complications, you may need surgery to remove the diseased part of your colon.

About 1 in 6 people who have had a C. diff infection will get it again within the following 2 to 8 weeks. This is called recurrent C. diff. It could be that your original infection came back or that you have a new infection. Contact your provider if your symptoms come back.

For people who keep getting C. diff infections, treatments such as fecal microbiota transplants (FMT) have shown promising results. FMT uses stool (or bacteria from stool) from a healthy donor to try to restore the balance of healthy bacteria in your intestines.

There are steps you can take to try to prevent getting or spreading C. diff:

  • Wash your hands with soap and water after you use the bathroom and before you eat.
  • If you have diarrhea, clean the bathroom that you used before anyone else uses it. Use bleach mixed with water or another disinfectant to clean the toilet seat, handle, and lid.

Health care providers can also help prevent C. diff infections by taking infection control precautions and improving how they prescribe antibiotics.

Centers for Disease Control and Prevention

It sits within Digestive System and Infections.

When to speak to someone. Reading about a topic cannot tell you whether it applies to you. Speak to a doctor or pharmacist if symptoms are severe, sudden, getting worse, or simply not going away — and seek emergency care immediately for chest pain, breathing difficulty, sudden weakness or confusion, or a serious allergic reaction.

Research on C. diff Infections

280 studies areregistered for this condition on ClinicalTrials.gov, the U.S. National Library of Medicine's public registry. A selection is below — the links go straight to the registry entry, not to a summary of ours.

What a registered study does and does not mean. Registration means a study exists and has been declared publicly. It says nothing about whether the treatment being tested works, is safe, or is available to you. Many studies find no benefit — that is what research is for. Never seek out an experimental treatment on the strength of a registry entry alone.

Research currently under way

Research already completed

Study data from ClinicalTrials.gov, a service of the U.S. National Library of Medicine. Retrieved 2026-07-30. Registry entries are supplied by study sponsors and investigators; ClinicalTrials.gov does not verify their scientific validity. PocketsInfo is not affiliated with, and not endorsed by, the NLM or the NIH.

Where to read more

Rather than paraphrase, we point you to the primary sources. Every link below is to a government health agency, a national institute or a recognised medical body — grouped by what you are trying to find out.

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Diagnosis and Tests

Treatments and Therapies

Clinical Trials

Patient Handouts

Medical subject headings

Clinicians and researchers index this subject under Clostridioides difficile, Enterocolitis, Pseudomembranous. These are the terms to use when searching medical literature.

This page is built from the MedlinePlus health topic record for C. diff Infections, a service of the U.S. National Library of Medicine (NLM), National Institutes of Health. Information is from MedlinePlus.gov. PocketsInfo is not affiliated with, and is not endorsed by, the NLM or the NIH. Retrieved 30 July 2026.