Common Signs of CREST and How Antibodies Help

Calcinosis: Calcium deposits under the skin, often on fingers, elbows, and knees, which can be painful and ulcerate.

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Raynaud's Phenomenon: Vasospasm of blood vessels in fingers and toes triggered by cold or stress, leading to discoloration and pain.

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Esophageal Dysmotility: Difficulty swallowing due to impaired esophageal muscle function, potentially causing gastroesophageal reflux disease (GERD).

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Sclerodactyly: Thickening and tightening of skin on fingers and hands, restricting joint mobility and causing flexion contractures.

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Telangiectasia: Dilated blood vessels visible on skin surfaces, particularly on face, hands, and mucous membranes.

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Anti-Centromere Antibody (ACA): A specific antibody found in 70-80% of CREST patients, aiding in diagnosis and distinguishing

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Antinuclear Antibody (ANA): Often positive in CREST patients, indicating autoimmune activity.

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ACA Role in Diagnosis: Presence of ACA antibodies supports CREST diagnosis, especially in patients with limited systemic sclerosis.

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Early Detection: Regular monitoring and early detection of lung issues and other complications are crucial for effective management and treatment.

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Antibody Testing: ACA testing helps diagnose CREST syndrome, distinguish it from other conditions, and guide treatment strategies

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For More Info

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